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Mitochondrial Antioxidant Therapy to Resolve Inflammation in Ulcerative Colitis

A good week for study, we recruited 4 (!) patients into MARVEL inc 1st patient in #Manchester thanks to Pro Limdi's wonderful team. Mitochondrial antioxidants in UC www.marvelstudy.uk. Novel ways to treat IBD. #ibd #ulcerativecolitis #mitochondria

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— Glasgow Gut Science (@glasgowgutscience.bsky.social) 14 February 2025 at 08:22

We're making good progress in our MARVEL IBD trial www.marvelstudy.uk oral mitochondrial antioxidants in Ulcerative Colitis. Thus week our fab team in #Glasgow recruited a further 2 patients, nearly n=60 (target 200). 😀 #ibd #Colitis #mitochondria #trials

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— Glasgow Gut Science (@glasgowgutscience.bsky.social) 7 February 2025 at 16:37

Marvel Study Overview

Marvel Study Design Overview
Lisa Derr introducing MARVEL

Introducing MARVEL

By Lisa Derr, Trial Manager

Marvel Recruitment Status

60 / 206 participants
Last updated: March 2025

Center Breakdown

Edinburgh
35
Glasgow
15
Pinderfields Hospital
4
Dundee
2
Darlington Memorial Hospital
2
Chelsea & Westminster
1
Fairfield General Hospital
1

I'm delighted to take forward the research findings over the last 10 years from my scientific team into a human clinical trial. This has been a journey involving many scientists, clinicians and also our patients. The MARVEL study will provide very much needed data to show whether this new treatment approach will work in Ulcerative Colitis.

DR GWO-TZER HO

Chief Investigator
Centre for Inflammation Research
University of Edinburgh

Gwo Tzer Ho

Sponsors

Jon Moulton Charity Trust
Centre for Inflammation Research
NHS Lothian
ACCORD

About Us

Centre for Inflammation ResearchCentre for Inflammation Research, Queen's Medical Research Institute
Centre for Inflammation Research Site OverviewEdinburgh BioQuarter Site Overview

Dr Gwo-Tzer Ho

Chief Investigator (Marvel)

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Professor David Wilson

Chief Investigator (mini-Marvel)

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Professor Chris Probert

Chair, Trial Steering Committee

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Professor Jonathan Rhodes

Chair, Data Monitoring Committee

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Michelle Wilson

Research Associate

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Dr Rebecca Hall

Clinical Research Fellow

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Dr Shaun Chuah

Clinical Research Fellow

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Beena Pouloose

Clinical Research Nurse

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Athena Oddy

Clinical Research Nurse

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Alix MacDonald

Trial Manager

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Lisa Derr

Trial Manager

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Katherine Lewis

Trial Support Officer

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